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How does it work?

HMB, chemically known as hydroxymethylbutyrate, is a metabolite of the branched chain amino acid leucine.1 HMB has anticatabolic activity which assists in the prevention of the breakdown of muscle protein, particularly during periods where muscle atrophy is accelerated, such as cachexia, AIDS and bedrest.2 This may also apply to athletes on a restricted diet where they are at risk of muscle depletion.3 It has also been shown that HMB supplementation increased lean muscle mass in older adults participating in weight training, without affecting fat mass.4 HMB may also cause slight increases in insulin release from the pancreas.5

What results can be expected?

HMB supplementation may assist in preventing muscle protein breakdown for those at risk of muscle depletion such as athletes, the elderly or severe illness.6 HMB may also increase lean mass in some individuals however further research is needed.7